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The Main Spheres of Research

  • Isolation and cultivation of human and animal stem cells, immunophenotypic characterization of stem cells
  • Study of the stem cells migration in the animal body using fluorescence and luminescence imaging in vivo
  • Study of the structural and functional changes during stem cells differentiation using  fluorescent proteins and different microscopy techniques  (STORM, FLIM, LSM) 
  • Assessment of the structure and quality of dermal equivalents by optical and multiphoton tomography
  • Proliferation and viability analysis of stem cells in 3D-scaffolds with different architectonics using optical bioimaging
  • Study of the involvement of allogeneic mesenchymal stem cells in bone formation

 

Selected publications

  1. Meleshina AV, Cherkasova EI, Shirmanova MV, Klementieva NV, Kiseleva EV, Snopova LВ, Prodanets NN, Zagaynova EV.  Influence of mesenchymal stem cells on the metastases development in mice in vivo. Stem Cell Res Ther. 2015; 6:15.

  2. Meleshina AV, Dudenkova VV, Shirmanova MV, Shcheslavskiy VI, Becker W, Bystrova AS, Cherkasova EI, Zagaynova EV. Probing metabolic states of differentiating stem cells using two-photon FLIM. Sci Rep. 2016;6:21853.

  3. Timashev P, Kuznetsova D, Koroleva A, Prodanets N, Deiwick A, Piskun Y, Bardakova K, Dzhoyashvili N, Kostjuk S, Zagaynova E, Rochev Y, Chichkov B, Bagratashvili V. Novel biodegradable star-shaped polylactide scaffolds for bone regeneration fabricated by two-photon polymerization. Nanomedicine (Lond). 2016;11(9):1041-53.

  4. Kuznetsova D, Prodanets N, Rodimova S, Antonov E, Meleshina A, Timashev P, Zagaynova E. Study of the involvement of allogeneic MSCs in bone formation using the model of transgenic mice. Cell Adh Migr. 2016 Jun 17:1-12.

Lab team

ELENA V. ZAGAYNOVA

DSc in Medicine, professor of the Russian Academy of Sciences

+7(831)4655626

ezagaynova@gmail.com

meleshina

ALEKSANDRA V. MELESHINA

Researcher, PhD in Biology

almele@ya.ru

kuznecova

DARIA S. KUZNETSOVA

Junior Researcher,  PhD-student

daria.s.kuznetsova@gmail.com

bystrova

ALENA S. BYSTROVA

Laboratory Assistant, Student

bystrova93@gmail.com