The Main Spheres of Research

  • Cultivation of tumor cells of animals and humans for in vitro and in vivo experiments
  • Obtaining cell lines from human primary tumors and metastases
  • Biological and genetic characteristics of cancer cells and fibroblasts
  • Testing of sensitivity of cancer cells to chemotherapy
  • Study of interaction of cancer cells and stroma in tumors and 3D tumor spheroids
  • Microenvironment in tumors

 

Selected publications

  1. Shirmanova MV, Druzhkova IN, Lukina MM, Matlashov ME, Belousov VV, Snopova LB, Prodanetz NN, Dudenkova VV, Lukyanov SA, Zagaynova EV. Intracellular pH imaging in cancer cells and tumors in vivo using new genetically encoded sensor SypHer2. Biochim Biophys Acta. 2015;1850(9):1905-11.
  2. Druzhkova IN, Shirmanova MV, Lukina MM, Dudenkova VV, Mishina NM, Zagaynova EV. The metabolic interaction of cancer cells and fibroblasts – coupling between NAD(P)H and FAD, intracellular pH and hydrogen peroxide. Cell Cycle. 2016 May 2;15(9):1257-66.

Lab team

shirmanova

MARINA V. SHIRMANOVA

PhD in Biophysics and Animal Physiology

+7(831) 4655672

shirmanovam@mail.ru

sirotkina

MARINA A. SIROTKINA

Researcher, PhD in Biology

sirotkina_m@mail.ru

drujkova

IRINA N. DRUZHKOVA

Junior Researcher, PhD-student

danirin@yandex.ru

kulagin

FEDOR A. KULAGIN

Laboratory Assistant, Student

frodor1993@mail.ru